Projects & Cores

The CTO articulates into three tightly integrated projects, under the unifying theme of the quest for a deeper understanding of the multi-scale differentials in transport properties that accompany and in several ways define the evolution of malignancies. These differentials manifest themselves with the emergence or the modulation of pathology-associated biophysical and biological barriers to transport. The operational corollary to the unifying basic science theme of this proposed CTO is the quest for innovative, physical science-based methodologies that afford the exploitation of these differentials for improved diagnostics and treatment of cancer.

Project 1: Directed transport physics and multi-scale therapy of colon cancer liver metastasis
Project Leaders: Mauro Ferrari Ph.D., Kenji Yokoi, M.D., Ph.D., Biana Godin Vilentchouk, Ph.D.

Project 2: Non-invasive radio-frequency field induced thermal destruction of malignant cells in human hepatocellular cancer. 
Project Leaders: Steven Curley, M.D., Renata Pasqualini, Ph.D., Lon Wilson, Ph.D.

Project 3: Genomic correlates of mass transport differentials. 
Project Leader: Neal Copeland, Ph.D., Nancy Jenkins, Ph.D., Haifa Shen, Ph.D.

Cores: Each of the Three projects are supported by the following cores.

• Core 1: BioMathematics Core. Core Leaders: Vittorio Cristini, PhD and Paolo Decuzzi, PhD
• Core 2: Advanced Intravital Microscopy core. Core Leader: Seok H. (Andy) Yun, PhD
• Core 3: Orthotopic Tumor Models.  Core Leaders: Kenji Yokoi, PhD and Biana Godin-Vilentchouk PhD.