Stephen Wong, Ph.D., P.E.

Stephen Wong, Ph.D., P.E.

	Stephen Wong, Ph.D., P.E. Senior Member John S Dunn Distinguished Endowed Chair in Biomedical Engineering Director, NCI Center for Modeling Cancer Development Director, The Ting Tsung and Wei Fong Chao Center for Bioinformatics Research and Imaging for Neuroscience Director, Center for Bioengineering and Informatics Department Chair  Department of Systems Medicine and Bioengineering The Methodist Hospital Research Institute  Director of Translational Research Methodist Cancer Center Chief Research Information Officer Chief of Medical Physics Vice Chair of Radiology The Methodist Hospital System Professor of Radiology Professor of Neuroscience Professor of Pathology and Laboratory Medicine Weill Cornell Medical College of Cornell University Adjunct Professor of Cellular and Molecular Biology Baylor College of Medicine Adjunct Professor of Diagnostic Radiology UT MD Anderson Cancer Center Adjunct Professor of Biomedical Informatics UT Health Sciences Center at Houston Adjunct Professor of Bioengineering, Electrical and Computer Engineering Rice University Adjunct Professor of Bioengineering and Mechanical Engineering University of Houston Phone: 713-441-5883 Fax: 713-441-8699 E-mail: stwong@tmhs.org
Education B.E.   (Hons). University of Western Australia, Perth, AU (Electrical Engineering) M.S.   Lehigh University, Bethlehem, PA (Computer Science & Engineering) Ph.D.   Lehigh University, Bethlehem, PA (Computer Science) Postdoctoral Training Japan Program Fellow, National Science Foundation, ICOT, The Fifth Generation Computer Systems Project, MITI, Tokyo, Japan Science and Technology Agency Fellow, Science and Technology Agency, Japan

Biography

Dr. Wong is the Founding Chairman for Department of Systems Medicine and Bioengineering, The Methodist Hospital Research Institute. He holds the John S. Dunn, Sr. Distinguished Endowed Chair in Biomedical Engineering; he is also a Professor of Radiology, Pathology, Laboratory Medicine, Neurology, and Neurosciences, the Associate Director of Translational Research at Methodist Cancer Center, and Chief of Medical Physics and Chief Research Information Officer at The Methodist Hospital. In addition, he serves as the Founding Director of the Ting Tsung and Wei Fong Chao Center for BRAIN (Bioinformatics Research and Imaging in the Neurosciences) and Founding Director of the Center for Modeling Cancer Development at The Methodist Hospital Research Institute. He also holds a dozen of other academic posts across institutions in Texas Medical Center as well as overseas universities and medical schools. An internationally acclaimed bioengineer and imaging scientist, Dr. Stephen Wong has led teams that developed production automation for first very large scale integration (VLSI) 1MB computer memory chip and the largest online brokerage trading system, and contributed to the first hospital-wide digital radiology image management system in US academic medical centers.

Dr. Wong has more than twenty years of research and management experience in industry and academia, including Hewlett-Packard, AT&T Bell Laboratories, the Japanese Fifth Generation Computer Systems Project, Philips Medical Systems and Royal Philips Electronics, Charles Schwab, University of California - San Francisco/Berkeley, Harvard University and The Methodist Hospital. He received his senior executive education from the MIT Sloan School of Management, Stanford University Graduate School of Business and Columbia University Graduate School of Business. He holds eight patents and has published over 300 peer-reviewed papers and four books. He also serves on and chairs NIH study panels, conference program committees, and the editorial boards of twelve scientific journals. As an international authority, he is sought as a speaker on medical imaging, systems biology, healthcare IT, drug development, biophotonics, clinical neuroscience and other related topics.

Description of Research

Dr. Wong's research focuses on understanding health and disease from a systems perspective in order to generate cost-effective strategies and solutions for disease management. His research approaches combine both experimental and high throughput biology with rigorous computational, bioinformatics, biophysics, and imaging methods to achieve a deep understanding of the functions of each component in biological systems and integration of them with multilevel systems analysis. For example, the consequences of genetic variation, cell-cell interactions and environmental factors are included to reflect the circumstances and microenvironments of the disease condition. Current research projects include pathway modeling and high throughput phenotyping approaches for target discovery and drug repurposing in combating neurological disorders and cancer, and for understanding the mechanisms of these diseases. Additional projects include reformulation of small molecule drugs using chemical biology approaches, the development of point-of-care molecular diagnosis and monitoring devices using biophotonics and nanotechnology techniques, and the development of label-free molecular image-guided cancer therapy platforms.

Major Areas of Research

Biological and medical imaging, bioinformatics and systems biology, drug repositioning and combinations, image-guided therapy, translational biophotonics, molecular imaging and diagnosis, and mechanisms of cancer and neurological disorders.

Recent Publications (selected from over 300 peer-reviewed papers)

Jin G, Fu C, Zhao H, Cui K, Chang J, Wong ST. A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy. Cancer Res. Jan 1;72(1):33-44, 2012. Pubmed ID: 22108825

Zhao H, Cui K, Nie F, Wang L, Brandl MB, Jin G, Li F, Mao Y, Xue Z, Rodriguez A, Chang J, Wong ST. The effect of mTOR inhibition alone or combined with MEK inhibitors on brain metastasis: an in vivo analysis in triple-negative breast cancer models. Breast Cancer Res Treat. 2012 Jan;131(2):425-36. Pubmed ID: 21394501

Sigoillot FD, Huckins JF, Li F, Zhou X, Wong ST, King RW. A time-series method for automated measurement of changes in mitotic and interphase duration from time-lapse movies. PLoS One. 2011;6(9):e25511. Epub 2011 Sep 26. Pubmed ID: 21966537

Li Q, Deng Z, Zhang Y, Zhou X, Nagerl V, Wong ST. A Global Spatial Similarity Optimization Scheme to Track Large Numbers of Dendritic Spines in Time-lapse Confocal Microscopy. IEEE Trans Med Imaging. 2011 Mar;30(3):632-41. Epub 2010 Nov 1. Pubmed ID: 21047709

Zhu X, Zhou X, Lewis MT, Xia L, Wong ST. Cancer stem cell, niche and EGFR decide tumor development and treatment response: A bio-computational Simulation Study. Journal of Theoretical Biology, 2011 Jan 21 269 (1):138-149. Pubmed ID: 20969880

Gong Z, Zhao H, Zhang T, Nie F, Pathak P, Cui K, Wang Z, Wong S, Que L. Drug effects analysis on cells using a high throughput microfluidic chip. Biomed Microdevices. 2011 Feb;13(1):215-9. Pubmed ID: 20978852

Alvarado MV, Wong KK, He TC, Xue Z, Wong ST. Image-Guided Fiberoptic Molecular Imaging in a VX2 Rabbit Lung Tumor Model. J Vasc Interv Radiol. 2011 Dec;22(12):1758-64. Pubmed ID: 22019854

Wang Z, Liu Y, Gao L, Chen Y, Luo P, Wong KK, Wong ST. Use of multimode optical fibers for fiber-based coherent anti-Stokes Raman scattering microendoscopy imaging. Opt Lett. 2011 Aug 1;36(15):2967-9. Selected for publication in Virtual Journal for Biomedical Optics. Pubmed ID: 21808374

Gao L, Li F, Thrall MJ, Yang Y, Xing J, Hammoudi AA, Zhao H, Massoud Y, Cagle PT, Fan Y, Wong KK, Wang Z, Wong ST. On-the-spot lung cancer differential diagnosis by label-free, molecular vibrational imaging and knowledge-based classification. J. Biomed. Opt. 16, 096004 (2011). Selected for the September 15, 2011 issue of Virtual Journal of Biological Physics Research. Pubmed ID: 21950918

Yang Y, Li F, Gao L, Wang Z, Thrall MJ, Shen SS, Wong KK, Wong ST. Differential diagnosis of breast cancer using quantitative, label-free and molecular vibrational imaging. Biomed Opt Express. 2011 Aug 1;2(8):2160-74. Epub 2011 Jul 5. Pubmed ID: 21833355

Wang Z, Gao L, Luo P, Yang Y, Hammoudi AA, Wong KK, Wong ST. Coherent anti-Stokes Raman scattering microscopy imaging with suppression of four-wave mixing in optical fibers. Opt Express. 2011 Apr 25;19(9):7960-70. Selected for publication in Virtual Journal for Biomedical Optics. Pubmed ID: 21643045

Gao L, Zhou H, Thrall MJ, Li F, Yang Y, Wang Z, Luo P, Wong KK, Palapattu GS, Wong ST. Label-free high resolution imaging of prostate glands and cavernous nerves using coherent anti-Stokes Raman scattering microscopy. Biomed Opt Express. 2011 Mar 18;2(4):915-26. Pubmed ID: 21483613

Tang AM, Ananta JS, Zhao H, Cisneros BT, Lam EY, Wong ST, Wilson LJ, Wong KK. Cellular Uptake and Imaging Studies of Gadolinium-loaded Single-walled Carbon Nanotubes as MRI Contrast Agents. Contrast Media Mol Imaging. 2011 Mar;6(2):93-9. doi: 10.1002/cmmi.410. Epub 2010 Dec 29. Pubmed ID:21504063

Hu X, Wong KK, Young GS, Guo L, Wong ST. Support vector machine multiparametric MRI identification of pseudoprogression from tumor recurrence in patients with resected glioblastoma. J Magn Reson Imaging. 2011 Feb;33(2):296-305. Pubmed ID: 21274970

Mok V, Wong KK, Xiong Y, Wong A, Schmidt R, Chu W, Hu X, Leung EY, Chen S, Chen Y, Tang WK, Chen X, Ho CL, Wong KS, Wong ST. Cortical and frontal atrophy are associated with cognitive impairment in age-related confluent white- matter lesion. J Neurol Neurosurg Psychiatry. 2011 Jan;82(1):52-7. Pubmed ID: 20826875

Srinivasan R, Li Q, Zhou X, Lu J, Lichtman J, Wong ST. Reconstruction of the neuromuscular junction connectome. Bioinformatics. 2010 Jun 15;26(12):i64-70. Pubmed ID: 20529938

Zhang Y, Chen K, Baron M, Teylan MA, Kim Y, Song Z, Greengard P, Wong ST. A neurocomputational method for fully automated 3D dendritic spine detection and segmentation of medium-sized spiny neurons. Neuroimage. 2010 May 1;50(4):1472-84. Pubmed ID: 20100579

Xia X, Yang J, Li F, Li Y, Zhou X, Dai Y, Wong ST. Image-based chemical screening identifies drug efflux inhibitors in lung cancer cells. Cancer Res. 2010 Oct 1;70(19):7723-33. Pubmed ID: 20841476

Wang Z, Yang Y, Luo P, Gao L, Wong KK, Wong ST. Delivery of picosecond lasers in multimode fibers for coherent anti-Stokes Raman scattering imaging. Opt Express. 2010 Jun 7;18(12):13017-28. Pubmed ID: 20588430

Mok VC, Wong A, Wong K, Chu WC, Xiong Y, Chan AY, Kwok TC, Hu X, Lee WK, Tang WK, Wong KS, Wong S. Executive dysfunction and left frontal white matter hyperintensities are correlated with neuropsychiatric symptoms in stroke patients with confluent white matter hyperintensities. Dement Geriatr Cogn Disord. 2010;30(3):254-60. Pubmed ID: 20847556

Li H, Xue Z, Guo L, Liu T, Hunter J, Wong ST. A hybrid approach to automatic clustering of white matter fibers. Neuroimage. 2010 Jan 15;49(2):1249-58. Pubmed ID: 19683061

Zhang S, Degraba TJ, Wang H, Hoehn GT, Gonzales DA, Suffredini AF, Ching WK, Ng MK, Zhou X, Wong ST. A novel peak detection approach with chemical noise removal using short-time FFT for prOTOF MS data. Proteomics. 2009 Aug 13;9(15):3833-3842. Pubmed ID: 19681055

Srinivasan R, Zhou X, Miller E, Lu J, Litchman J, Wong ST. Automated axon tracking of 3D confocal laser scanning microscopy images using guided probabilistic region merging. Neuroinformatics: Volume 7, Issue 1 (2009), Page 8. Pubmed ID: 17917130

Zhao H, Tang C, Cui K, Ang BT, Wong ST. A screening platform for glioma growth and invasion using bioluminescence imaging. J Neurosurg. 2009 Aug;111(2):238-46. Pubmed ID: 19199503

Kwong KK, Kloetzer L, Wong KK, Ren JQ, Kuo B, Jiang Y, Chen YI, Chan ST, Young GS, Wong ST. Bioluminescence Imaging of Heme Oxygenase-1 Upregulation in the Gua Sha Procedure. J Vis Exp. 2009 Aug 28;(30). pii: 1385. doi: 10.3791/1385. Pubmed ID: 19718012

Links

TMHRI Department of Systems Medicine and Bioengineering

Center for Bioengineering and Informatics

Center for Modeling Cancer Development

The Ting Tsung and Wei Fong Chao Center for Bioinformatics Research and Imaging for Neuroscience

Texas Screening Alliance for Cancer Therapeutics