Traditionally the first line of treatment for people diagnosed with HOCM is drug therapy. Medications called beta-blockers and calcium channel blockers are very effective in helping the heart pump more efficiently and controlling blood pressure. Almost all patients experience some level of benefit from treatment with these drugs, but as the disease progresses, they usually become less effective. In addition, antiarrhythmic drugs can be used in people who experience palpitations. If used carefully, diuretics can help to relieve shortness of breath.