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Stanley H. Appel, M.D.
Director, Methodist Neurological Institute
Peggy and Gary Edwards Distinguished Endowed Chair in ALS Research
Chair, Department of Neurology
Professor of Neurology
Weill Cornell Medical College
6560 Fannin Street, Suite 802
Houston, TX 77030
Phone: 713-441-3760
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Stanley H. Appel, M.D. is the Director of the Methodist Neurological Institute, Peggy and Gary Edwards Distinguished Endowed Chair in ALS Research and Chair, Department of Neurology. He is also Professor of Neurology at Weill Cornell Medical College. Dr. Appel was previously Chair of the Department of Neurology at Baylor College of Medicine as well as Chief of the Neurology division and the James B. Duke Professor of Medicine at Duke University Medical Center, North Carolina.
Dr. Appel is a native of Massachusetts and received his Bachelor Degree at Harvard University and his Medical Degree from Columbia College of Physicians and Surgeons. He is Director of the MDA/ALS Research and Clinical Center at the Methodist Neurological Institute, and past Director of a National Institute of Aging Alzheimer's Disease Research Center.
Clinical Expertise:
- Amyotrophic Lateral Sclerosis
- Alzheimer’s disease
- Neuromuscular diseases
- Parkinson’s disease
- Multisystem atrophy
Research Interests:
Mechanisms of neuronal injury and death in ALS, Parkinson's disease, and Alzheimer's disease. Cell lines as well as animal models are being used to define the pathways of cell injury and triggering factors such as autoimmunity. Increased intracellular calcium is one of the key constituents being studied.
Education:
- M.D. Columbia College of Physicians & Surgeons, New York, NY
- Resident in Neurology, Mount Sinai Hospital, New York, NY
- Research Associate, Laboratory of Molecular Biology, National Institutes of Health, Bethesda, MD
- Visiting Scientist, Visiting Scientist in Genetics and Neurology, Jackson Laboratory, Bar Harbor, ME
- Associate in Medicine (Neurology), Duke University Medical Center, Durham, NC
- Chief Resident in Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA
Selected Publications:
- Kano O, Beers DR, Henkel JS, Appel SH. Peripheral nerve inflammation in ALS mice: cause or consequence. Neurology. 2012 Mar 13;76(11):833-5.
- Appel SH. Inflammation in Parkinson’s disease: Cause or Consequence? Mov Disord. 2012 Aug;27(9):1075-7
- Zhao W, Beers DR, Henkel JS, Liao B, Appel SH. Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms. Neurobiol Dis. 2012 Dec;48(3):418-428.
- Appel SH, Rowland LP. Amyotrophic lateral sclerosis, frontotemporal lobar dementia, and p62: a functional convergence? Neurology. 2012 Oct 9;79(15):1526-7.
- Henkel JS, Beers DR, Wen S, Rivera AL, Toennis KM, Appel JE, Zhao W, Moore DH, Powell SZ, Appel SH. Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival. EMBO Mol Med. 2012. 4,1-16.
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