The Center for Transport Oncophysics (CTO), through its three projects and three cores, is focusing on the study of a coordinated, fundamental subset of all active biobarriers in cancer and to utilize the knowledge gained to design and develop therapeutic nanotechnologies for cancer treatment. The CTO website has more information on the investigators, projects and cores: http://www.methodisthealth.com/cto.
However, the CTO projects and cores cannot and are not intended to cover all the biophysical and biological barriers that play important roles in the cancer growth and invasion. The pilot and outreach pilot projects will be utilized to supplement the proposed CTO projects and cores in the studies of biophysical and biological barriers.
The fundamental strategy is to supplement our investigations of biobarriers in cancer and transport mechanisms pertaining to diagnosis, therapy, imaging, and modeling through the pilot and outreach pilot project programs. The qualified proposals from the CTO investigators will be supported through the Pilot Project mechanism. Collaboration between CTO investigators and external investigators will be supported through Outreach Pilot Project mechanism.
Collaborators from institutions other than the member institutions are allowed, but no funding can be requested for these collaborators (with the exception of the Outreach Pilot Projects).
Proposal due date: March 16, 2012, 5:00pm (CST)
Planned Start Date: June 1, 2012
The Pilot Projects Program is intended to fund important new pilot/feasibility projects focused on biophysical and biological barriers concepts in cancer that develop a new research direction, explore an innovative idea, or test an unconventional, but potentially important new hypothesis.
Projects are funded for one year, with the possibility of a second year of support awarded upon demonstration of sufficient progress.
Pilot project funds are to be spent primarily on supplies and trainee salaries, rather than on faculty salary support. Proposal budgets should reflect this requirement.
Applications should be simple and brief and should include and be ordered as follows:
Please provide a detailed one-year budget (e.g. NIH PHS 398 Form Page 4 showing detail for materials and supplies, travel, etc.).
Pilot project funds are to be spent only on supplies and trainee salaries, rather than on faculty salary support. No indirect costs will be supported. Proposal budgets should reflect this requirement.
Applications should be emailed to: firstname.lastname@example.org
Awardees must provide a 500 word summary of the research plans, understandable to lay people, at the time of funding, and an additional 500 word summary of their research accomplishments, also understandable to lay people, at the completion of funding. Awardees will also be expected to present their progress at the Annual CTO Workshop.
Publications generated as a result of funding support should acknowledge the funding source as follows:"The research described was supported by Award Number U54CA143837 from the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health."
Applicants are required to send a 5-page final report at 12 months.
The review procedure will be a two-tier process that involves a first step review by an internal review committee appointed by the CAC to exclude proposals that have serious programmatic defects, i.e., incomplete proposal, lack of critical components and irrelevance to the proposed CTO or PS-OC aims.
The CAC members will conduct the 2nd level review based on the following criteria:
Please direct any questions or concerns regarding this RFA to Nina Neal, Project Manager, Department of NanoMedicine, The Methodist Hospital Research Institute: email@example.com, Phone: 713- 441- 4889.