Breast Cancers
BP22572 T-DM1 in Breast Cancer
Study Status: Active/Enrolling
Investigator: Chang, Jenny
Study Coordinator: Froehlich, Amber
Phone: 713-441-0685
Summary:This open-label, multi-center study will assess the safety and tolerability of adding trastuzumab emtansine (T-DM1) to docetaxel in patients with locally advanced or metastatic HER2-positive breast ca...(read more)
CAT Trial
Study Status: Active/Enrolling
Investigator: Chang, Jenny
Study Coordinator: Salazar, Maria
Phone: 713-441-6011
Summary:The major purpose of this research study is to better understand how therapy works on different patients. This study is being offered to patients with a diagnosis of advanced or metastatic breast canc...(read more)
Denosumab - Breast Cancer
Study Status: Active/Enrolling
Investigator: Chang, Jenny
Study Coordinator: Boone, Toniva
Phone: 7134410686
Summary:Purpose: This randomized phase 3 trial is studying the effect of denosumab to see if it can prevent disease recurrence in the bone or in any other part of the body, when it is given as adjuvant therap...(read more)
ECOG 2108
Study Status: Active/Enrolling
Investigator: Chang, Jenny
Study Coordinator: Salazar, Maria
Phone: 713-441-6011
Summary:RATIONALE: Early surgery may have fewer side effects and improve recovery. Palliative surgery or radiation therapy may help patients with advanced breast cancer live more comfortably. It is not yet kn...(read more)
Ganetespib STA-9090 for Metastatic HER2 Positive or Triple Negative Breast Cancer
Study Status: Active/Enrolling
Investigator: Rodriguez, Angel
Study Coordinator: Salazar, Maria
Phone: 713-441-6011
Summary:The purpose of this study is to determine if ganetespib (STA-9090) is effective in the treatment of patients with HER2+ or triple negative breast cancer who have not received prior systemic treatment ...(read more)
ICE Trial
Study Status: Active/Enrolling
Investigator: Chang, Jenny
Study Coordinator: Salazar, Maria
Phone: 713-441-6011
Summary:Ixabepilone and capecitabine combination has demonstrated to be an active regimen in patients with metastatic breast cancer (MBC) after failing an anthracycline and a taxane regimen. Cetuximab is acti...(read more)
M12-895 Abbott Phase II
Study Status: Active/Enrolling
Investigator: Chang, Jenny
Study Coordinator: Salazar, Maria
Phone: 713-441-6011
Summary:The Study Evaluating Efficacy And Tolerability of Veliparib in Combination with Temozolomide or Veliparib/Placebo in Combination with Carboplatin and Paclitaxel in Subjects with Breast Cancer Gene (BR...(read more)
MEDI573 in Metastatic Breast Cancer
Study Status: Active/Enrolling
Investigator: Rodriguez, Angel
Study Coordinator: Salazar, Maria
Phone: 713-441-6011
Summary:This is a Phase 1b/2, multicenter, open-label study to evaluate the safety, tolerability, antitumor activity, and pharmacology of MEDI-573 in combination with an AI in adult subjects with HR+, HER2-ne...(read more)
Neoadjuvant Gene Expression Profile
Study Status: Active/Enrolling
Investigator: Rodriguez, Angel
Study Coordinator: Boone, Toniva
Phone: 7134410686
Summary:This phase II trial is studying how well hormone therapy or chemotherapy before surgery based on gene expression analysis works in treating patients with breast cancer(read more)
NSABP B43
Study Status: Active/Enrolling
Investigator: Chang, Jenny
Study Coordinator: Sinclair, Toni
Phone: (713) 441-1159
Summary:RATIONALE: Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or...(read more)
NSABP B47
Study Status: Active/Enrolling
Investigator: Chang, Jenny
Study Coordinator: Sinclair, Toni
Phone: (713) 441-1159
Summary:RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination ch...(read more)
NSABP DMP1
Study Status: Active/Enrolling
Investigator: Chang, Jenny
Study Coordinator: Sinclair, Toni
Phone: (713) 441-1159
Summary:This clinical trial studies factors influencing decision-making about the use of chemoprevention in women at increased risk for breast cancer.(read more)
PROMIS registry of mammaprint in breast cancer
Study Status: Active/Enrolling
Investigator: Rodriguez, Angel
Study Coordinator: Sinclair, Toni
Phone: (713) 441-1159
Summary:This is a prospective registry study that will assess the impact of MammaPrint on chemotherapy + endocrine versus endocrine alone treatment decisions in patients with an Oncotype Intermediate Score.(read more)
S0812 Vitamin D in High Risk Breast Cancer
Study Status: Active/Enrolling
Investigator: Rodriguez, Angel
Study Coordinator: Sinclair, Toni
Phone: (713) 441-1159
Summary:RATIONALE: Cholecalciferol may prevent breast cancer in premenopausal women.
PURPOSE: This randomized phase II trial is studying how well cholecalciferol works in preventing breast cancer in premenop...(read more)
S0927 Omega-3 for the Control of AI Induced Musculoskeletal Pain
Study Status: Active/Enrolling
Investigator: Rodriguez, Angel
Study Coordinator: Sinclair, Toni
Phone: (713) 441-1159
Summary:RATIONALE: An omega-3 fatty acid-enriched nutritional supplement may help improve muscle and bone pain and stiffness caused by hormone therapy in patients with breast cancer.
PURPOSE: This randomized...(read more)
SWOG 1007
Study Status: Active/Enrolling
Investigator: Rodriguez, Angel
Study Coordinator: Sinclair, Toni
Phone: (713) 441-1159
Summary:RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy, using tamoxifen citrate, may fight breast cancer by blocking the use of estrogen by the tumor cells. Aromatase inhibit...(read more)
TDM4884g TDM1 for HER2 positive Locally Advanced or Metastatic Breast Cancer
Study Status: Active/Enrolling
Investigator: Chang, Jenny
Study Coordinator: Salazar, Maria
Phone: 713-441-6011
Summary:This is a multicenter, open-label, single-arm, expanded access study designed to provide T-DM1 to patients with HER2-positive locally advanced or metastatic breast cancer and to evaluate the safety an...(read more)
Trial of Active Immunotherapy With Globo H-KLH (OPT-822) in Metastatic Breast Cancer Subjects
Study Status: Active/Enrolling
Investigator: Rodriguez, Angel
Study Coordinator: Salazar, Maria
Phone: 713-441-6011
Summary:The purpose of this study is to compare active immunotherapy (OPT-822/OPT-821) with PBS in combination with low dose cyclophosphamide, in post-treated metastatic breast cancer subjects with stable dis...(read more)
Triple Negative RAD 001
Study Status: Active/Enrolling
Investigator: Chang, Jenny
Study Coordinator: Froehlich, Amber
Phone: 713-441-0685
Summary:RATIONALE: Drugs used in chemotherapy, such as cisplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Everol...(read more)
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Diabetes Mellitus
EXAMINE
Study Status: Active/Enrolling
Investigator: Hamilton, Dale
Study Coordinator: Whipple, Melissa
Phone: 713-441-3247
Summary:The purpose of this study is to evaluate the cardiovascular outcomes of alogliptin, once daily (QD), compared with placebo, in addition to standard of care, in subjects with type 2 diabetes mellitus a...(read more)
EXSCEL
Study Status: Active/Enrolling
Investigator: Wyne, Kathleen
Study Coordinator: Coverdale, Catrina
Phone: 713-441-3927
Summary:This study will compare the impact of including exenatide once weekly as part of usual care vs. usual care without exenatide on major cardiovascular outcomes as measured by the primary cardiovascular ...(read more)
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