Investigators

Federico Monzon-Bordonaba, M.D.

 

	Federico Monzon-Bordonaba, M.D. Assistant Member Director, Research Pathology and Molecular Diagnostics Cores The Methodist Hospital Research Institute Medical Director, Molecular Diagnostics Department of Pathology and Laboratory Medicine The Methodist Hospital Physician Organization Assistant Professor of Pathology and Genomicf Medicine Weill Cornell Medical College of Cornell University   E-mail: famonzon@tmhs.org Phone: 713-441-3291 Fax: 713-441-1565
Education M.D. Medicine, Universidad Nacional Autonoma de Mexico, School of Medicine, Mexico City, Mexico Postdoctoral Training Postdoctoral fellowship, Reproductive Biology, University of Pennsylvania, Philadelphia, PA Pathology Rfesidency, Anatomic and Clinical Pathology, Thomas Jefferson University Hospital, Philadelphia, PA Clinical fellowship, Molecular Genetic Pathology, University of Pittsburgh, Pittsburgh, PA

Biography

Dr. Monzon received his M.D. from the National University in Mexico City and spent several years conducting basic research at the Instituto Nacional de Cancerologia in Mexico City and at the University of Pennsylvania in Philadelphia. He completed his AP/CP residency training at Thomas Jefferson University Hospital in Philadelphia and Molecular Genetic Pathology subspecialty training at the University of Pittsburgh.

Description of Research

Dr. Monzon is involved in research projects that involve the application of genomic knowledge as a clinical tool. His main research focus is the use of chromosome copy number applications for the molecular classification of renal cell carcinoma. The objective of this project is to use genomic data to classify morphologically difficult renal epithelial neoplasms and to identify new biomarkers for prognosis and response to therapy. Dr. Monzon is also interested in the use of gene expression profiling for the diagnosis of tumors of uncertain primary.

Major Areas of Research

renal cell carcinoma, gene expression profiling

Recent Publications

Powers MP, Alvarez K, Kim HJ, Monzon FA. Molecular Classification Diagn Mol Pathol. 2010, in press

Monzon FA, Medeiros F, Lyons-Weiler M, Henner WD. Identification of tissue of origin in carcinoma of unknown primary with a microarray-based gene expression test. Diagn Pathol. 2010 Jan 13;5:3.

Monzon FA, Koen TJ. Diagnosis of metastatic neoplasms: molecular approaches for identification of tissue of origin. Arch Pathol Lab Med. 2010 Feb;134(2):216-24. Review.

Hagenkord JM, Monzon FA, Kash SF, Lilleberg S, Xie Q, Kant JA. Array-based karyotyping for prognostic assessment in chronic lymphocytic leukemia: performance comparison of Affymetrix 10K2.0, 250K Nsp, and SNP6.0 arrays. J Mol Diagn. 2010 Mar;12(2):184-96.

Monzon FA, Dumur CI. Diagnosis of uncertain primary tumors with the Pathwork tissue-of-origin test. Expert Rev Mol Diagn. 2010 Jan;10(1):17-25. Review.

Monzon FA, Alvarez K, Gatalica Z, Bridge JA, Nelson M, Kim HJ, Hagenkord JM. Detection of chromosomal aberrations in renal tumors: a comparative study of conventional cytogenetics and virtual karyotyping with single-nucleotide polymorphism microarrays. Arch Pathol Lab Med. 2009 Dec;133(12):1917-22.

Monzon FA, Ogino S, Hammond ME, Halling KC, Bloom KJ, Nikiforova MN. The role of KRAS mutation testing in the management of patients with metastatic colorectal cancer. Arch Pathol Lab Med. 2009 Oct;133(10):1600-6. Review.

Kang HP, Hagenkord JM, Monzon FA, Parwani AV. Residency training in pathology informatics: a virtual rotation solution. Am J Clin Pathol. 2009 Sep;132(3):404-8.

Kim HJ, Shen SS, Ayala AG, Ro JY, Truong LD, Alvarez K, Bridge JA, Gatalica Z, Hagenkord JM, Gonzalez-Berjon JM, Monzon FA. Virtual-karyotyping with SNP microarrays in morphologically challenging renal cell neoplasms: a practical and useful diagnostic modality. Am J Surg Pathol. 2009 Sep;33(9):1276-86.

Monzon FA, Lyons-Weiler M, Buturovic LJ, Rigl CT, Henner WD, Sciulli CM, Dumur CI, Medeiros F & Anderson GG. Clinical Validation of a Gene Expression Test for Identification of Tumor Tissue of Origin. J Clin Oncol. 2009 May 20;27(15):2503-8.

Monzon FA, Hagenkord J, Lyons-Weiler M, Balani JP, Parwani AV, Sciulli CM, Li J, Chandran U, Bastacky S, and Dhir R. Whole Genome SNP Arrays as a Diagnostic Tool for Detection of Chromosomal Aberrations in Renal Tumors. Mod Pathol. 2008 May;21(5):599-608

Links

Federico A. Monzon, Medical Director, Molecular Diagnostics, Department of Pathology and Laboratory Medicine, The Methodist Hospital

Molecular Genetic Pathology (MGP) Fellowship Program