Department of Neurology: Physicians & Scientists
Stanley H. Appel, MD
Professor of Neurology
Weill Medical College of Cornell University
Peggy and Gary Edwards Distinguished Endowed Chair
for the Treatment and Research of ALS
Chair, Department of Neurology
Director, MDA-ALS Research and Clinical Center
Co-Director of the Methodist Neurological Institute
M.D.(1960) Columbia College of Physicians & Surgeons
6560 Fannin St. Suite 802
Houston, TX 77030
Phone: 713-441-3760 Fax: 713-793-7271
Clinical Interests:
Neuromuscular disorders, Neurodegenerative diseases: Amyotrophic Lateral Sclerosis, Alzheimer's disease, and Parkinson's disease.
Research Interests:
Mechanisms of neuronal injury and death in ALS, Parkinson's disease, and Alzheimer's disease. Cell lines as well as animal models are being used to define the pathways of cell injury and triggering factors such as autoimmunity. Increased intracellular calcium is one of the key constituents being studied.
Selected Publications:
- Beers DR, Henkel JS, Xiao Q, Zhao W, Wang J, Yen AA, Siklos L, McKercher SR, Appel SH. (2006) “Wild-Type Microglia Extend Survival in PU.1 Knockout Mice with Familial Amyotrophic Lateral Sclerosis”. PNAS. 103(43):16021-6.
- Zhao W, Xie W, Xiao Q, Beers DR, Appel SH. (2006) “Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia”. J Neurochem. 1459-1471.
- Czaplinski A, Yen AA, Simpson EP, and Appel SH. (2006) “Slower disease progression and proglonged survival in comtemporary patients with Amyotrophic Lateral Sclerosis”. Arch Neurol. 63(8):1139-1143.
- Goldknopf IL, Sheta EA, Bryson J, Folsom B, Wilson C, Duty J, Yen AA, Appel SH.(2006) "Complement C3c and related protein biomarkers in amyotrophic lateral sclerosis and Parkinson's disease".Biochem Biophys Res Commun.21;342(4):1034-9.
- Appel SH.(2006) "Is ALS a systemic disorder? Evidence from muscle mitochondria".
Exp Neurol. 198(1):1-3. - Czaplinski A, Yen AA, Appel SH. (2006) "Forced vital capacity (FVC) as an indicator of survival and disease progression in an ALS clinic population". J Neurol Neurosurg Psychiatry.77(3):390-2.
- Sheta EA, Appel SH, Goldknopf IL. (2006) "2D gel blood serum biomarkers reveal differential clinical proteomics of the neurodegenerative diseases". Expert Rev Proteomics. 3(1):45-62.
- Henkel JS, Beers DR, Siklos L, Appel SH.(2005) "The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS". Mol Cell Neurosci.31(3):427-37.
- Yoshor D, Klugh A 3rd, Appel SH, Haverkamp LJ.(2005) "Incidence and characteristics of spinal decompression surgery after the onset of symptoms of amyotrophic lateral sclerosis".
Neurosurgery. 57(5):984-9. - Simpson EP, Appel SH. (2005) "Individual and health-related quality of life assessment in amyotrophic lateral sclerosis patients and their caregivers" by Lo Coco G, Lo Coco D, Cicero V, Oliveri A, Lo Verso G, Piccolo F, La Bella V. J Neurol Sci. 15;238(1-2):1-2.
- Ringholz GM, Appel SH, Bradshaw M, Cooke NA, Mosnik DM, Schulz PE. (2005) "Prevalence and patterns of cognitive impairment in sporadic ALS". Neurology. 23;65(4):586-90.
- Das A, Sribnick EA, Wingrave JM, Del Re AM, Woodward JJ, Appel SH, Banik NL, Ray SK. (2005) "Calpain activation in apoptosis of ventral spinal cord 4.1 (VSC4.1) motoneurons exposed to glutamate: calpain inhibition provides functional neuroprotection". J Neurosci Res. Aug 15;81(4):551-62.
- Vigh L, Smith RG, Soos J, Engelhardt JI, Appel SH, Siklos L. (2005) "Sublethal dose of 4-hydroxynonenal reduces intracellular calcium in surviving motor neurons in vivo". Acta Neuropathol (Berl). 109(6):567-75.
- Zhao W, Xie W, Le W, Beers DR, He Y, Henkel JS, Simpson EP, Yen AA, Xiao Q, Appel SH. (2004) "Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism". J Neuropathol Exp Neurol.63(9):964-77.
Official Health Care Provider of:
Awards and Recognition:
